Since the Agricultural College was founded for the reclamation of Hokkaido, education initially promoted such subjects as zoology and botany, entomology, and soil science. Although there were many courses of study in common between the Sapporo Agricultural College and that in Massachusetts, further courses in the humanities and social sciences were incorporated at the former for the purpose of providing a total well-rounded cultural education. As a result of this kind of education, a large number of competent individuals were graduated, especially in the fields of natural science and technology. The following are eight representative scientists produced by the University:

MIYABE Kingo (Botany: 1860–1951)
ITO Seiya (Plant Pathology, Mycology: 1883–1962)
KIHARA Hitoshi (Genetics: 1893–1986)
WATASE Shozaburo (Biogeography: 1862–1929)
ICHIKAWA Koichi (Veterinary Science, Pathology: 1888–1948)
HIROI Isami (Civil Engineering: 1862–1928)
MATSUMURA Shonen (Entomology: 1872–1960)
HATTA Saburo (Ontogeny: 1865–1935)